副教授
石松林
发布时间: 2022年01月05日浏览次数:


石松林 副教授

学科(方向):肿瘤细胞生物学/肿瘤转移与肝纤维化

所在系部:基础医学部

办公电话:0592-2185363

邮    箱:shisonglin@xmu.edu.cn


研究领域:

肿瘤转移是癌症发生后致死的主因,而肝纤维化-肝硬化过程则是我国特色的肝癌发生前的重要阶段。近几年来我们的研究领域主要集中于核仁磷酸化蛋白NPMRNA结合蛋白hnRNPA2/B1等重要调控蛋白在肿瘤的发生与转移方面的作用与机制研究,以及在肝纤维化过程中的作用与机制研究。

学习经历:

1993~1997  安徽大学生命科学学院微生物学,  理学学士;

2001~2007  厦门大学生命科学学院细胞生物学, 理学博士(直博)。

工作经历:

2007~2009  厦门大学化学化工学院        博士后;

2009~2012  yl23411永利官网登录              助理教授;

2014~2015  美国宾夕法尼亚大学医学院    访问学者;

2012~至今  yl23411永利官网登录              副教授。

代表性成果:

1. 通讯作者论文

  1. Yu Liu#, Huan Li#,Fan Liu#, Li-Bin Gao#, Rong Han#, Chen Chen, Xue Ding, Shuang Li, Kun Lu, Ling Yang, Hui-Min Tian,Bin-Bin Chen,Xiao Li, Dong-Hui Xu, Xiao-Ling Deng, Song-Lin Shi*. Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways. Ebiomedicine 2020 Jan; 51: 102583.

  2. Yuling Hong#, Haifeng Qin#, Yin Li#, Yuhai Zhang, Xunrong Zhuang, Lei Liu, Kun Lu, Long Li, Xiaoling Deng, Fan Liu, Fan Liu*, Songlin Shi*, Guoyan Liu*.FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E‐cadherin and CD44 expression. J Cell Physiol. 2019 Nov; 234(11):19895-19910.

  3. Kun Lu, Gang Rui, Fan Liu, Ling Yang, Xiao-Ling Deng Song-Lin Shi* and Qi-Fu Li*. 14‑3‑3ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin‑induced apoptosis of MG‑63 cells. Oncology Letters, 2018,15: 338-346.

  4. Li-Chun Zheng #, Xiao-Qing Wang #, Kun Lu #, Xiao-Ling Deng, Cheng-Wei Zhang, Hong Luo, Xu-Dong Xu, Xiao-Man Chen, Lu Yan, Yi-Qing Wang*, Song-Lin Shi*. Ephrin-B2/Fc promotes proliferation and migration, and suppresses apoptosis in human umbilical vein endothelial cells. Oncotarget, 2017, Jun 20; 8(25): 4134841363.

  5. Guo-Yan Liu#, Jing-Xian Shi#, Song-Lin Shi#,*,Fan Liu, Gang Rui, Xiao Li, Li-Bin Gao,Xiao-Ling Deng and Qi-Fu Li*.Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6. Journal of Cellular Biochemistry, 2017, 118:46974707

  6. Xiao Li#Dong-Hui Xu#Fan Liu#Guo-Yan Liu,  Kun Lu, Xiao-Ling Deng Qi-Fu Li*, Song-Lin Shi*. Relocation of NPM Affects the Malignant Phenotypes of Hepatoma SMMC-7721 Cells. Journal of Cellular Biochemistry , 2017, 118:32253236

  7. Kun Lu#,Guoyan Liu#, Ling Yang#, Fan Liu,Libin Gao, Jingxian Shi, Xiaoling Deng, Qifu Li, Donghui Xu, Songlin Shi*. Sustainable inflammation transforms hepatic cells by causing oxidative stress injury and potential epithelial-mesenchymal transition. International Journal of Oncology, 2016, 49: 971980.  

  8. Bo Peng#, Fan Liu#, Rong Han#, George Luo, Terry Cathopoulis, Kun Lu, Xiao Li, Ling Yang, Guo-Yan Liu, Jian-Chun Cai*, Song-Lin Shi*. Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells. The International Journal of Biochemistry & Cell Biology, 2015,66:4558.

  9. Dong-Hui Xu#, Fan Liu#, Xiao Li, Xiang-Feng Chen, Guang-Jun Jing, Fu-Yun Wu, Song-Lin Shi*, Qi-Fu Li*. Regulatory role of nucleophosmin during the differentiation of human liver cancer cells. International Journal of Oncology, 2014, 45: 264272.

  10. 刘凡,陈兰英,黄建,刘用金,石松林(*),热休克蛋白70在人食管癌EC9706细胞凋亡过程中的表达与定位变化,解剖学报,2012,43(04):490-499.

2. 第一作者论文

  1. 石松林,赵振利,王国红,刘凡,路锟,杨玲,韩荣,李晓,李祺福(*)Prohibitin在姜黄素诱导人成骨肉瘤MG-63细胞凋亡过程中的调控机制,解剖学报,2015,4601:72-80.

  2. 石松林,陈兰英,刘用金,杨海波,路锟,杨玲,李祺福(*)姜黄素诱导人食管癌EC9706细胞凋亡过程中核磷蛋白的表达与定位变化,解剖学报,2014,45(02):224-230.

  3. Liang, Ying (#), Shi, Song-Lin(#), Li, Qi-Fu (*) Chen, Lan-YingJing, Guang-JunTan, Guo-WeiWang, San-YingWu, Fu-YunThe Localization of hnRNP A2/B1 in Nuclear Matrix and the Aberrant Expression During the RA-Induced Differentiation of Human Neuroblastoma SK-N-SH CellsJournal of Cellular Biochemistry2011.1127):1722-1729.

  4. Shi, Song-Lin(#), Dan, Bing(#), Liu, Fan(#), Lin, Li-RongFu, Zuo-GenJing, Guang-Jun,Yang,Tian-Ci(*),Zhang,Zhong-Ying(*),Synthesis and characterization of a novel cationic polymer gene delivery vector. International Journal of Molecular Medicine2010.26(4):491-500.

  5. Shi, Song-LinLiang, YingLi, Qi-Fu(*), Liu, Qing-RongJing, Guang-JunWang, San-Ying, Zhang, Xiu-Yan, Wu, Fu-YunLocalization of Nucleophosmin in Nuclear Matrix and Changes in Its Expression During the Differentiation of Human Neuroblastoma Induced by Retinoic Acid,Journal of Cellular Biochemistry, 2010,111(1)67-74.

  6. Shi, Song-Lin., Li, Qi-Fu(*) Liu, Qing-RongXu, Dong-HuiTang, JianLiang, YingZhao, Zhen-LiYang, Li-MingNuclear Matrix Protein, Prohibitin, Was Down-Regulated and Translocated From Nucleus to Cytoplasm During the Differentiation of Osteosarcoma MG-63 Cells Induced by Ginsenoside Rg1. Cinnamic acid, and Tanshinone IIA (RCT)Journal of Cellular Biochemistry, 2009,108(04):926-934.

  7. 石松林,李祺福(*),王国红,马宗源,史建陆,林昌健,人参皂甙Rg1对人成骨肉瘤MG-63细胞形态结构和终末分化指标的影响,厦门大学学报(自然科学版)2009,48(03):392-398.

  8. 石松林,黄晓明,李祺福(*),王三英,杨海波,文昌鱼鳃组织原代培养,海洋科学,2009,33(03):44-48

  9. 石松林,李祺福(*),刘庆榕,许东辉,唐剑,梁盈,人参皂苷Rg1组合诱导人成骨肉瘤MG-63细胞分化过程中Prohibitin的表达与定位变化,中国生物化学与分子生物学报,2008,24(02):180-187.

  10. 石松林,王国红,李祺福(*),马宗源,林昌健,赵振利,人参皂甙Rg1、肉桂酸和丹参酮IIA组合对成骨肉瘤MG-63细胞增殖与相关基因表达的影响,细胞生物学杂志,2008,30(06):761-765.

  11. 石松林,李祺福(*),郑燕彬,唐剑,陈平,人参皂甙Rg1组合对人成骨肉瘤MG-63细胞分化过程中核基质构型与蛋白质组成的影响,解剖学报,2008, 39(05):670-676.

  12. 石松林,王国红,马宗源,史建陆,林昌健,李祺福(*)丹参酮IIA对人成骨肉瘤MG-63细胞形态结构和终末分化指标的影响,现代生物医学进展,2008,8(05):801-805.

  13. Shi, Song-Lin,Wang, Yong-Ye,Liang, Ying,Li, Qi-Fu(*). Effects of tachypiesin and n-sodium butyrate on proliferation and gene expression of human gastric adenocarcinoma cell line BGC-823,World Journal of Gastroenterology, 2006,12(11):1694-1698.

主持过的重要课题:

  1. 国家自然科学基金面上项目《核磷蛋白NucleophosminNPM)在肝硬化进程中的作用与分子机制研究》(2017-2020,编号:81670542;在研)

  2. 国家自然科学基金面上项目 《HnRNP A2/B1 在乳腺癌细胞中的作用及分子机制》(2013.01-2016.12,编号:81272921;已结题)

  3. 福建省卫生教育联合攻关项目《核磷蛋白NPM表达与定位异常在肝细胞癌变中作用研究》(2014-2016,编号:WKJ-FJ-16. 合作单位主持人,已结题)

  4. 省自然科学基金《Prohibitin 在肿瘤细胞诱导分化中的表达与定位变化及其蛋白相互作用研究》(2008-2010,编号:2008J0302;已结题)

  5. 省自然科学基金《核基质蛋白PHB与肿瘤细胞癌变与逆转关系研究》(2011.04-2014.03,编号:2011J01256;已结题);

  6. 中央高校基本科研业务费项目《 HnRNP A2/B1在人肝癌细胞癌变与逆转过程中调控机理研究》(2011-2013,编号:2011121061;已结题)。

  7. 博士后科学基金《一种新核基质蛋白 Prohibitin在肿瘤细胞分化中表达与定位变化及其蛋白相互作用研究》(2007-2009,编号:20070420754;已结题);




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